Abstract
BackgroundAlthough the prevalence of kidney disease is higher in those with reduced lung function, the longitudinal relationship between low lung function and future risk of chronic kidney disease (CKD) has not been widely explored.MethodsBaseline lung function was assessed in 20,700 men and 7325 women from 1974 to 1992. Mean age was 43.4 (±6.6) and 47.5 (±7.9) for men and women respectively. Sex-specific quartiles of FEV1 and FVC (L) were created (Q4: highest, reference) and the cohort was also divided by the FEV1/FVC ratio (≥ or < 0.70). Cox proportional hazards regression was used to determine the risk of incident CKD events (inpatient or outpatient hospital diagnosis of CKD) in relation to baseline lung function after adjustment for various confounding factors.ResultsOver 41 years of follow-up there were 710 and 165 incident CKD events (main diagnosis) in men and women respectively. Low FEV1 was strongly associated with future risk of CKD in men (Q1 vs Q4 adjusted HR: 1.46 (CI:1.14–1.89), p-trend 0.002). Similar findings were observed for FVC in men (1.51 (CI:1.16–1.95), p-trend 0.001). The adjusted risks were not found to be significant in women, for either FEV1 or FVC. FEV1/FVC < 0.70 was not associated with increased incidence of CKD in men or women.ConclusionLow FEV1 and FVC levels at baseline are a risk factor for the development of future incident CKD in men. Monitoring kidney function in those with reduced vital capacity in early life could help with identifying those at increased risk of future CKD.
Highlights
The prevalence of kidney disease is higher in those with reduced lung function, the longitudinal relationship between low lung function and future risk of chronic kidney disease (CKD) has not been widely explored
The hazard ratios (HR) of incident CKD events by quartiles of forced expiratory volume in 1 s (FEV1) for men and women are shown in Tables 3 and 4, respectively
Discussion a cross-sectional relationship between low lung function and CKD previously has been found in subjects with chronic obstructive pulmonary disease (COPD) [25, 27, 28], the longitudinal relationship between low lung function early in life and the future risk of incident CKD has not been as widely established Our study investigates this longitudinal relationship in over 28,000 subjects in the Malmö Preventive Project (MPP) cohort
Summary
The prevalence of kidney disease is higher in those with reduced lung function, the longitudinal relationship between low lung function and future risk of chronic kidney disease (CKD) has not been widely explored. Chronic kidney disease (CKD) has become an important public health issue [1]. It encompasses substantial morbidity and mortality globally along with important economic implications to health systems [1, 2]. It is an independent risk factor for cardiovascular disease (CVD), which in turn is a major cause of the morbidity and mortality associated with CKD [2]. There has been some cross-sectional research assessing the relationship between low lung function and CKD [25,26,27,28,29], we are aware of few studies assessing the role of lung function in the prediction of incident kidney disease [30, 31], which have found low lung function to be independently associated with CKD progression
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
