Abstract
Therefore, we defined the objective of our research: to study the factors of uterine cervix tissue im- munity for women with Chlamydia infection and to estimate the effect of low-intensity laser therapy (LILT) on these factors due to a wavelength of 632 nm and a power of 30 mW. Materials and methods. Clinical immunologic studies of cervical secretion were carried out on 184 women of reproductive age 25,9 ± 4,22 in 2016–2018. Chlamydia infection Chlamydia trachomatis was found by the methods of real-time polymerase chain reaction (Rt-PCR) tests. Code by Classifier of the International Standard Classification of Diseases and Related Health Problems 10th Revision is А 56.0, Chlamydial infections of the lower sections of the urogenital tract. Urethra and canalis cervicis uteri scrapings were used as the material for detecting C. trachomatis. All patients with chlamydial infection of the lower part of the urogenital system were divided into two groups: a group of 100 women who were treated by using the local influence of the low-intensity laser of 632 nm as a part of complex treatment, the comparison group (basic treatment) consisted of 84 women who took azithromycin of 1 g once a day for the 1st, 5th, 10th days of treatment. 50 healthy women without any pathology and infections of the genitourinary system made the control group. A system of cytokines was studied by interleukin's level IL-8. IL-1 α, IL-1 β, TNF-α and IFN-γ content in cervical mucus. Results Course. The results of the study showed a high clinical and immunological efficacy of treating chlamydial cervicitis using a low intensity laser with a wavelength of 632 nm. An imbalance of cellular factors of innate immunity revealed before starting a therapy: a decrease in the oxygen-dependent metabolism of neutrophilic granulocytes of the cervical secretion.
Highlights
Chlamydia infection is one of the most widespread sexually transmitted diseases
The efficiency of its treatment largely depends on the condition of the factors of the local anti-infective protection of the reproductive tract, so studying the immune reactions at the local level, i.e. directly in the affected area, may be an important field in searching for pathogenetic therapy and it stipulates the search for the ways of therapeutic modality onto the patient’s organism both at the system and local level [2]
Cytokine system was studied via interleukin content 1α, 1β, 8 (IL-1α, IL-1β, IL-8), factors of tumor necroses α — FTNα and interferon γ (IFN-γ) in cervical secretion were studied by Enzyme-linked immunosorbent assay (ELISA)
Summary
Chlamydia infection is one of the most widespread sexually transmitted diseases. The efficiency of its treatment largely depends on the condition of the factors of the local anti-infective protection of the reproductive tract , so studying the immune reactions at the local level, i.e. directly in the affected area, may be an important field in searching for pathogenetic therapy.we defined the objective of our research: to study the factors of uterine cervix tissue immunity for women with Chlamydia infection and to estimate the effect of low-intensity laser therapy (LILT) on these factors due to a wavelength of 632 nm and a power of 30 mW. The efficiency of its treatment largely depends on the condition of the factors of the local anti-infective protection of the reproductive tract , so studying the immune reactions at the local level, i.e. directly in the affected area, may be an important field in searching for pathogenetic therapy. The efficiency of its treatment largely depends on the condition of the factors of the local anti-infective protection of the reproductive tract , so studying the immune reactions at the local level, i.e. directly in the affected area, may be an important field in searching for pathogenetic therapy and it stipulates the search for the ways of therapeutic modality onto the patient’s organism both at the system and local level [2]. The aim of the study was to define the objective of our research: to characterize the factors of cervical secretion tissue immunity for women with Chlamydia infection and to estimate the effect of low-intensity laser radiation (radiation power — 30 mW, wavelength — 632 nm) upon these factors
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