Abstract
Electric low-frequency stimulation (LFS) of afferent nerve fibers reliably induces long-term depression (LTD) of synaptic transmission in vitro. LTD is suggested to be one important mechanism of synaptic plasticity in the mammalian brain. The study demonstrated an LTD of evoked cortical potentials (−30%) and perception ratings (−25%) by noxious electric LFS of trigeminal afferents in man, indicating that LTD may also be involved in human synaptic plasticity.
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