Abstract
s / Brain Stimulation 8 (2015) 412e427 415 K groups showed a similar IEG expression profile except that K group showed greater upregulation of c-jun mRNA expression in the dentate gyrus and hippocampal CA1-3 region. Because c-jun is involved in neuronal cell death in adult brain, the increased c-jun expression suggests enhanced neuronal apoptosis in the K+Q group. Further study should determine if quenching blocks kindlinginduced seizure development by selective degeneration of kindling-activated neurons and/or pathological pathways.
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