Low expression of lncRNA UCA1 assists the diagnosis of type 2 diabetes mellitus and predicts an increased risk of cardiovascular complications

Abstract

ABSTRACT Type 2 diabetes mellitus (T2DM) is a leading global health concern. The study estimated the lncRNA UCA1 expression in peripheral blood of T2DM patients and its clinical value for diagnosing T2DM and predicting cardiovascular disease (CVD) in T2DM. A total of 80 T2DM patients (37 cases with T2DM complicated with CVD) were selected, with another 70 healthy people as controls. UCA1 expression was measured, and its diagnostic efficacy for T2DM was assessed. Median UCA1 level divided T2DM patients into UCA1 low expression group and UCA1 high expression group, and its correlation with clinical indicators of T2DM patients was analyzed. Relevance between UCA1 and SADN, YKL-40 or CTRP-3 in T2DM complicated with CVD patients, and independent correlation between UCA1 and CVD in T2DM were evaluated. UCA1 was downregulated in T2DM patients, associated with clinical indicators, and assisted the diagnosis of T2DM. UCA1 was positively-correlated with SADN and CTRP-3, and negatively interrelated with YKL-40. UCA1 low expression was independently linked with and predicted an enhanced risk of CVD in T2DM patients. Briefly, UCA1 low expression assists the diagnosis of T2DM and predicts an increased risk of CVD in T2DM patients.