Abstract
In a controlled clinical trial, using the 125I-fibrinogen test, low-dose subcutaneous heparin was more effective in preventing postoperative deep-venous thrombosis (D.V.T.) than were routine oral anticoagulants. The frequency of thrombosis was 2% (1 out of 50) in the heparin group and 18% (9 out of 50) in the acenocoumarol (nicoumalone) group. This high incidence of thrombosis in patients on oral anticoagulants was unexpected. Earlier reports had shown a significant reduction in clinically evident D.V.T and lethal pulmonary em- bolism found at necropsy. The efficacy of routine oral anticoagulation had not, however, been tested with the help of an objective measure such as the 125I-fibrinogen test. Further investigation comparing these two methods as far as the prevention of lethal pulmonary embolism is concerned is indicated.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
