Low-dose aspirin for oocyte donation recipients with a thin endometrium: prospective, randomized study

Abstract

Objective: To evaluate the effect of low-dose aspirin use in oocyte donation recipients with an endometrial thickness of <8 mm. Design: A prospective, randomized study. Setting: An oocyte donation program in a private infertility practice. Patient(s): Twenty-eight recipients undergoing oocyte donation who failed to develop an endometrial thickness of at least 8 mm in a previous evaluation cycle. Intervention(s): Fifteen recipients received low-dose aspirin (81 mg/d) in addition to standard hormone replacement for an oocyte donation cycle. The remaining 13 recipients did not receive aspirin. Main Outcome Measure(s): Clinical pregnancy rates, delivery rates, implantation rates, and change in endometrial thickness were compared in the aspirin and nonaspirin groups. Result(s): There was no demonstrable increase in endometrial thickness in the aspirin-treated group. However, there was a statistically significant increase in implantation rates in the aspirin-treated group (24% versus 9%) and in implantation rates and clinical pregnancy rates in the aspirin-treated group when the final endometrial thickness was <8 mm. Conclusion(s): Low-dose aspirin therapy improves implantation rates in oocyte donation recipients with a thin endometrium.