Abstract
We present a low-cost, compact, and multispectral spatial frequency domain imaging prototype. Illumination components, including 9 LEDs (660 nm - 950 nm) placed on a custom-designed printed circuit board, linear and rotational motors, a printed sinusoidal pattern, and collimation and projection optics as well as the detection components are incorporated in a compact custom-designed 3D-printed probe. Reconstruction of absorption and reduced scattering coefficients is evaluated via imaging tissue mimicking phantoms and potentials of the probe for biological tissue imaging are evaluated via imaging human ovarian tissue ex vivo.
Highlights
Optical properties of tissue may vary in healthy and diseased conditions, optical imaging modalities capable of providing quantitative maps of absorption and scattering properties can assist in characterization of healthy versus diseased tissue [1,2]
Initial reports of Spatial frequency domain imaging (SFDI) systems utilized general-purpose projectors, with built-in digital micro-mirror devices (DMDs), to project the spatially sinusoidal patterns, generated from a computer connected to the projector, on the tissue [3,4,5,8]
An external DMD controlled by a PC [1], or a printed sinusoidal pattern [9] provide the spatial modulation of light that is projected on the tissue
Summary
Optical properties of tissue may vary in healthy and diseased conditions, optical imaging modalities capable of providing quantitative maps of absorption and scattering properties can assist in characterization of healthy versus diseased tissue [1,2]. Initial reports of SFDI systems utilized general-purpose projectors, with built-in digital micro-mirror devices (DMDs), to project the spatially sinusoidal patterns, generated from a computer connected to the projector, on the tissue [3,4,5,8]. An external DMD controlled by a PC [1], or a printed sinusoidal pattern [9] provide the spatial modulation of light that is projected on the tissue. Such systems generally utilize four LEDs [1]. Incorporating and co-aligning larger number of LEDs in such setups requires many optical components which increase the size, cost, and complexity of the system. In visible DLPs, which are the more common versions, RGB LEDs are collimated and co-
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