Abstract
Mercurials at low concentrations suppress oxidative phosphorylation in isolated rat kidney mitochondria. The kidneys of rats administered toxic doses of HgCl 2 have been found to accumulate mercury selectively compared e.g. to liver. Mitochondria isolated from such kidneys are defective in coupled ATP synthesis. Providing the time subsequent to the injection of a toxic dose of HgCl 2 does not exceed a critical time, the defect in the mitochondria isolated from the kidneys of such poisoned rats is correctable by addition of Mg++ to the assay medium. Acute mercury toxicity in rats appears to be referable to the impairment of kidney function in turn caused by impairment of mitochondrial function.
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More From: Biochemical and Biophysical Research Communications
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