Abstract
Patients carrying heterozygous germline truncating mutations in the CYLD gene develop multiple primary hair follicle related tumours. A highly organised tumour, termed cylindroma, and a highly disorganised tumour, termed spiradenoma, may both develop in the same patient. Furthermore, histological features of both tumour types have been described within the same tumour specimen. We used three-dimensional computer-aided reconstruction of these tumours to explore growth patterns of cylindromas and spiradenomas.
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