Abstract
Loss of function of Ywhah in mice induces deafness and cochlear outer hair cell’s degeneration
Highlights
These results support the notion that Bcl-2 family proteins such as Bax and Bad are critical for the maintenance of hearing function.[11]
This study shows the essential role of 14-3-3eta in OHC survival
A primary function of 14-3-3 proteins is the inhibition of apoptosis by retaining proapoptotic factors like Bad or Bax in the cytoplasm.[2,3] proteins were originally discovered as abundant molecules in the brain,[3] comprising about 1% of total proteins of the brain
Summary
These results support the notion that Bcl-2 family proteins such as Bax and Bad are critical for the maintenance of hearing function.[11].
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