Loss memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effect

Abstract

Previous studies have indicated that chronic exercise mimics some of the central nervous system effects observed after antidepressant drug treatment. The purpose of this work was to investigate the possible effect of lithium treatment in mice swimmers in the animals models of anxiety and memory. The mice were evaluated at the elevated plus-maze, open-field, Morris water maze and object recognition. Adult male Swiss mice were divided in four groups: control sedentary (CS), lithium sedentary (LS), control swimming exercise (CE), and lithium swimming exercise (LE), treated either with normal chow or with chow containing with 0,25% lithium carbonate for 30 days. The results suggest that lithium treatment, swimming exercise or lithium treatment combined with swimming exercise induces an anxiolytic-like effect in mice in the elevated plus-maze test. These symptoms were observed in LS as an increase in time spent in the open arms and open arms entries (F = 3.238; p 0,05). The present study found that swimming exercise and/or lithium treatment induced an anxiolytic-like effect, indicating that interactions between physical activity and/or lithium may be beneficial. However, the lithium treatment prevents the increase in learning and memory improvement induced by swimming exercise. The results provide evidence that stimulates investigation of the possibility that swimming exercise, in conjunction with lithium treatment, could represent a new approach to improvement of behavioral management in depression.