Abstract
AbstractThe aim of present study was to develop a simple, rapid, selective, sensitive and robust reverse phase high‐performance liquid chromatography method for quantification of Lornoxicam and internal standard meloxicam in rabbit plasma at the wavelength of 370 nm. Protein was precipitated from rabbit plasma sample by addition of acetonitrile as a vehicle. An isocratic elution of samples was performed on capcell pak C8 column with the mobile phase consisting 5 mM phosphate buffer (pH 4.8): methanol (40:60 v/v) delivered at flow rate 1.0 mL min−1. The method was quantitatively evaluated in terms of System suitability, linearity, precision, recovery, selectivity, robustness and stability studies. The validated reverse phase high‐performance liquid chromatography method was successfully applied for the bioavailability studies of Lornoxicam. The pharmacokinetic parameters were calculated for all the investigated drugs in rabbit plasma after single‐dose administrations of pure drug and formulation of Lornoxicam. Thus, developed method is simple, convenient and suitable for the analysis of Lornoxicam in bulk drug and pharmaceutical formulations.
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