Long-term Results of Colorectal Liver Metastases Surgery from Aspect of Primary Tumour Localisation

Abstract

Introduction: The aim of the study was to evaluate the influence of primary localisation of tumour for the long-term results of colorectal liver metastases (CLMs) surgery. Method: Prospectively collected data from whole group (WG) of 650 patients with CLMs were retrospectively analysed. The WG was divided according to localisation of the tumour into right-, left – sided colorectal cancer (RSCC, LSCC) and rectal cancer (RC). We evaluated the influence of localisation of primary tumour with regard to age, gender, size, number of CLMs, type of liver surgery and interval from primary operation on overall survival (OS) and recurrence free survival (RFS) of patients. Results: One-, three- and five-year OS and RFS respectively independent of side localisation of primary tumour (p<0.59). The diameter of CLMs was significant for OS of WG - p< 0.002, RSCC (p< 0.03) and LSCC (p< 0.04), for RFS only in the case of LSCC (p< 0.04). The number of CLMs was important for RFS of WG ( p< 0.0001), RSCC (p< 0.02), LSCC (p< 0.0001) and RC ( p<0.02). Radiofrequency ablation and combined operations had worse OS in the case of WG (p<0.03), RFS in the case of WG (p< 0.0003) and LSCC (p<0.03). A longer interval between operations was unexpectedly risky for OS in the case of LSCC (p< 0.05), shorter interval for RFS in the case of RSCC and LSCC – p<0.05 and p< 0.02 respectively. Conclusions: CLMs surgery from LSCC has poorer long-term results compared with other side localisations of primary tumour.