Long-term home oxygen therapy combined with aerosol inhalation of budesonide for COPD

Abstract

Objective To evaluate the clinical effect of long-term home oxygen therapy combined with aerosol inhalation of budesonide in the treatment of chronic obstructive pulmonary disease (COPD) . Methods Eighty-six patients with stable COPD were randomly divided into a control group and an observation group, 43 for each group. The control group were given conventional symptomatic therapy; in addition, the observation group were given long-term home oxygen therapy and aerosol inhalation of budesonide. The clinical effects were compared between the two groups. Results The total effective rate was 93.02% in the observation group and 76.74% in the control group (P<0.05) . The FEV1, FVC, and FEV1/FVC were significantly higher after than before the treatment in both groups (all P<0.05) , and were so in the observation group than in the control group after the treatment (all P<0.05) . The times for disappearance of shortness of breath, cough disappearance, and lung arpeggios were significantly shorter in the observation group than in the control group (all P <0.05) . Conclusions Long-term home oxygen therapy combined with aerosol inhalation of budesonide for chronic obstructive pulmonary disease can improve clinical efficacy, tissue oxygen supply, patients’ respiratory function and quality of life, and disease progression. Key words: Chronic obstructive pulmonary disease; Long-term home oxygen therapy; Budesonide; Pulmonary function