Abstract
Introduction: A hyperproteic diet normally results in acute changes in renal function evidenced by increases of natriuresis and glomerular filtration rate (renal functional reserve).Objectives: To assess the changes in natriuresis and creatinine clearance during 12 weeks on hyperproteic and hypersodic diet. Materials and Methods: Eighteen adults male Holtzman rats were included and the follow-up period was 12 weeks. The rats were initially distributed into three groups; hyperproteic diet (30%) from an animal source (n = 6), hyperproteic diet (30%) from a plant source (n = 6) and normoproteic diet (18%) from an animal source (n = 6). The diets were isocaloric, normosodic (0.25%). From week 8, each group was divided into three rats each and received a high-sodium (1.5%) and normosodic diet (0.25%) respectively. Results: The hyperproteic diet group (animal or plant vegetal source) had higher creatinine clearance than normoproteic diet (P < 0.05). The hyperproteic vegetal diet group had a peak with an increased renal functional reserve in 21% (P = 0.04). The natriuresis increased in the group on the animal-source diet during the first 2 weeks (P = 0.03). The group plant-source diet did not have significant change at the first week (P = 0.50); however, there was a subsequent decrease in the level of natriuresis between weeks 3 to 8. When the groups were exposed to a hypersodic diet, there was not difference in the natriuretic response between the groups (P > 0.05). Conclusion: A hyperproteic vegetal diet increased renal functional reserve but not natriuresis during an acute or long-term period; however, the natriuretic response was not impaired when a hypersodic diet was added, though hyperfiltration was present.
Highlights
A hyperproteic diet normally results in acute changes in renal function evidenced by increases of natriuresis and glomerular filtration rate
This study evaluates expected increases of glomerular filtration rate (GFR) on hyperproteic diet (renal functional reserve [8,9] during the acute and long term
The hyperproteic diet group had higher creatinine clearance than the group given the normoproteic diet at weeks 4 and 8 (P < 0.05)
Summary
A hyperproteic diet normally results in acute changes in renal function evidenced by increases of natriuresis and glomerular filtration rate (renal functional reserve). Objectives: To assess the changes in natriuresis and creatinine clearance during 12 weeks on hyperproteic and hypersodic diet. The hyperproteic vegetal diet group had a peak with an increased renal functional reserve in 21% (P = 0.04). The natriuresis increased in the group on the animal-source diet during the first 2 weeks (P = 0.03). Conclusion: A hyperproteic vegetal diet increased renal functional reserve but not natriuresis during an acute or long-term period; the natriuretic response was not impaired when a hypersodic diet was added, though hyperfiltration was present. A hyperproteic diet normally results in acute changes in renal function evidenced by increases of natriuresis and GFR (renal functional reserve). A longterm hyperproteic diet could induce sustained sodium reabsorption on excess protein intake [5]
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