Abstract
BackgroundOverweight and obesity are considered major health problems that contribute to increase mortality and quality of life. Both conditions have a high prevalence across the world reaching epidemic numbers. Our aim was to evaluate the effects of the administration of Garcinia cambogia (GC) and Glucomannan (GNN) on long-term weight loss in people with overweight or obesity.MethodsProspective, not-randomized controlled intervention trial was conducted. We treated 214 subjects with overweight or obesity with GC and GNN (500 mg twice a day, each) for 6 months evaluating weight, fat mass, visceral fat, basal metabolic rate, and lipid and glucose blood profiles comparing them with basal values. Some patients were carriers of polymorphisms PLIN4 -11482G > A-, fat mass and obesity-associated (FTO) -rs9939609 A/T- and β-adrenergic receptor 3 (ADRB3) -Trp64Arg.ResultsTreatment produced weight loss, reducing fat mass, visceral fat, lipid and blood glucose profiles while increasing basal metabolic rate. Results were independent of sex, age or suffering from hypertension, diabetes mellitus type 2 or dyslipidemia and were attenuated in carriers of PLIN4, FTO, Trp64Arg polymorphisms.ConclusionsAdministration of GC and GNN reduce weight and improve lipid and glucose blood profiles in people with overweight or obesity, although the presence of polymorphisms PLIN4, FTO and ADRB3 might hinder in some degree these effects. ISRCTN78807585, 19 September 2017, retrospective study.
Highlights
Overweight and obesity are considered major health problems that contribute to increase mortality and quality of life
It has been reported that PLIN gene and with several described polymorphism such as PLIN1 6209 T → C, PLIN4 11482G → A and PLIN6 14995A → T have been associated with obesity development or protection [16, 17]
Intervention effect in weight and basal metabolic rate, fat mass and visceral fat We first analyzed whether the treatment of people with overweight or obesity with Garcinia cambogia (GC) and GNN had any effect of weight, metabolic basal rate, fat mass and visceral fat
Summary
Overweight and obesity are considered major health problems that contribute to increase mortality and quality of life. Both conditions have a high prevalence across the world reaching epidemic numbers. It has been reported that PLIN gene (located in chromosome 15) and with several described polymorphism such as PLIN1 6209 T → C, PLIN4 11482G → A and PLIN6 14995A → T have been associated with obesity development or protection [16, 17]. ADRB3 polymorphism Trp64Arg has been strongly associated to obesity and DM2 [19] Activation of this receptor plays a role in lipolysis and thermogenesis regulation [15]
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