Abstract
Long-term choline alfoscerate (αGFC) treatment counteracts age-dependent structural changes in the hippocampus of Sprague-Dawley rats. Animals treated with a daily dose of 100 mg/kg αGFC from 18 to 24 months of age had more cells in the CA-1 to CA-3 fields and in the dentate gyrus compared to age-matched cohorts. The density of silver-gold stained fibers within the stratum oriens of the CA-1 to CA-2 fields was greater in rats treated with αGFC than in age-matched controls. The ramifications of these findings are discussed. © 1992 Wiley-Liss, Inc.
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