Abstract
Long-lasting insecticidal nets to prevent visceral leishmaniasis in the Indian subcontinent; methodological lessons learned from a cluster randomised controlled trial.
Highlights
Albert Picado1, Bart Ostyn2, Suman Rijal3, Shyam Sundar4, Shri Prakash Singh5, François Chappuis6, Murari Lal Das7, Basudha Khanal7, Kamlesh Gidwani4, Epco Hasker2, Jean Claude Dujardin8,9, Veerle Vanlerberghe2, Joris Menten2, Marc Coosemans8,9, Marleen Boelaert2*
We designed a controlled trial (CRT) to demonstrate a 50% reduction on the risk of L. donovani infection associated to the village-wide distribution of Insecticide treated nets (ITNs) [6]
The main conclusion of the trial was that “there is no evidence that using lasting insecticidal nets (LNs) as a public health intervention provides additional protection against Visceral leishmaniasis (VL) at community level compared with existing control practices in India and Nepal
Summary
The main conclusion of the trial was that “there is no evidence that using LNs as a public health intervention provides additional protection against VL at community level compared with existing control practices in India and Nepal (e.g., irregular use of untreated nets and IRS) This does not mean that the use of LNs in those VL endemic regions should be dismissed, as they may provide some degree of personal protection against sand flies [13] and have been shown to reduce the risk of malaria [6].
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