Abstract
Objective To study the HBeAg spontaneous seroconversion among chronic HBV infection.Methods A chronic HBV infection cohort with 172 HBsAg/HBeAg positive carriers was set up through the cross-sectional serological survey in 8 villages of Zhengding county,Hebei province in 1999,2005 and 2006.Serum specimens were collected from all carriers during the follow-up at 2010 and 2012,and were tested for anti-HBs,HBsAg,anti-HBe,HBeAg,HBV DNA,as well as ALT.Results Loss of HBeAg were detected from 32 carriers,the annual rate was 2％ (95％ CI:1.4％-2.8％).Of these,HBeAg seroconversion occurred in 26 carriers,the annual spontaneous HBeAg seroconversion rate was 1.6％ (95％CI:1.1％-2.4％).Conclusion Spontaneous HBeAg seroconversion could be observed in rare cases among chronic HBV carriers,coming along with the significant decrease of HBV DNA and HBsAg level. Key words: Hepatitis B virus; Carrier; HBeAg; Spontaneous seroconversion
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