Abstract
Early life stress (ELS) is linked to anxiety and substance use disorders. We examined the neurodevelopmental underpinnings of increased risk for cocaine (COC) abuse during adolescence using a translational macaque ELS model. ELS alterations in stress/emotion and reward regions (prefrontal cortex-PFC-, amygdala-AMY-, hippocampus-HIPP-, nucleus accumbens-NAcc-) have been reported during infancy/juvenile periods. Here, we investigated the long-term structural effects of ELS on these circuits during adolescence and whether they predict increased COC self-administration (SA).
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