Abstract
Editorial: Molecular Mechanisms for Reprogramming Hippocampal Development and Function by Early-Life Stress.
Highlights
The hippocampal formation is both a key component of the medial temporal lobe crucial for declarative memory and a main target of stress mediators and stress-related molecules
Most studies so far focus on the mechanisms of the long-term impact of early-life stress on hippocampal plasticity in adolescence/adulthood, which are of clinical relevance
We initiated this research topic to sum up recent findings with an emphasis on both the dynamic effects of early-life stress on hippocampal structure and function at different life stages and the immediate effects of stress on hippocampal development
Summary
The hippocampal formation is both a key component of the medial temporal lobe crucial for declarative memory and a main target of stress mediators (e.g., glucocorticoids and neuropeptides) and stress-related molecules (e.g., nutritional factors and cytokines). Molecular Mechanisms for Reprogramming Hippocampal Development and Function by Early-Life Stress Molecular mechanisms on how stress shapes the developing hippocampus have received attention only recently (Gross et al, 2012; Wei et al, 2012, 2015; Suri et al, 2013; Liao et al, 2014).
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