Abstract
Although it has been reported that chronic kidney disease exacerbates sarcopenia progression, the mechanisms of the process remain unclear. Fifty-one patients who underwent renal transplantation at our hospital since 1998 (31 males and 20 females; aged 29–52 years at the time of transplantation) were retrospectively examined for the relationships among the psoas muscle index (PMI), intramuscular adipose tissue content (IMAC), serum adiponectin fractions (high-/low-molecular-weight) and new-onset diabetes after transplantation (NODAT). Before transplantation, age at kidney transplantation negatively correlated with PMI and positively correlated with IMAC (rS = − 0.427, p < 0.01; rS = 0.464, p < 0.01, respectively). Both at 1 and 5 years after transplantation, PMI was higher than before transplantation (p < 0.01). IMAC transiently decreased to − 0.39 at 1 year after kidney transplantation but subsequently increased to − 0.36 at 5 years after kidney transplantation. Multivariate analyses revealed that the mean increase in high-molecular weight adiponectin concentrations was an exacerbating factor for the mean change in PMI (p = 0.003). Moreover, the mean increases in IMAC were exacerbating factors for NODAT. In conclusion, the increase in the PMI is associated with high–molecular weight adiponectin levels after renal transplantation.
Highlights
It has been reported that chronic kidney disease exacerbates sarcopenia progression, the mechanisms of the process remain unclear
As the quantity and quality of skeletal muscle is an essential component for sarcopenia, we focused on psoas muscle images on computed tomography (CT)
No difference was observed in age between the gender at transplantation or duration of dialysis, body mass index (BMI) and serum albumin was higher in males
Summary
It has been reported that chronic kidney disease exacerbates sarcopenia progression, the mechanisms of the process remain unclear. Fifty-one patients who underwent renal transplantation at our hospital since 1998 (31 males and 20 females; aged 29–52 years at the time of transplantation) were retrospectively examined for the relationships among the psoas muscle index (PMI), intramuscular adipose tissue content (IMAC), serum adiponectin fractions (high-/low-molecularweight) and new-onset diabetes after transplantation (NODAT). In addition to inflammatory processes, ADPN may contribute in cellular metabolism It plays a role in the onset of diabetes. Some ADPN fractions are speculated to play critical roles in the onset or progression of sarcopenia and newly onset diabetes, detailed studies on ADPN and sarcopenia in kidney transplantation are few. We examined muscle mass and fatty degeneration as sarcopenia markers and evaluated relationships between these factors and serum ADPN levels. We found that HMW-ADPN levels indicate increase of muscle mass until 5 years after kidney transplantation
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