Abstract
OBJECTIVE: to evaluate the long-term results of complex treatment of patients with locally advanced tongue cancer (T3-4N0-3M0) using modified selective intra-arterial polychemotherapy and systemic polychemotherapy. METHODS: depending on the polychemotherapy regimen, taking into account the designated classifications, all patients were divided into two groups. The study group included 51 patients who received intra-arterial (group VA) polychemotherapy according to the PF regimen, followed by radiation therapy. The control group included 50 patients who received intravenous (group IV) polychemotherapy according to the PF regimen, followed by radiation therapy. With positive dynamics in the VA group and the BB group (partial tumor regression), surgical treatment was performed in the amount of hemiglossectomy. In case of complete tumor regression, the 2nd stage of the telegammatherapy course on the tongue was performed up to a total dose of 60 Gy. In case of oncological process stabilization, the 2nd stage of the telegammatherapy course on the tongue was performed up to a total dose of 60 Gy, followed by palliative courses of systemic polychemotherapy. In case of disease progression, palliative courses of systemic polychemotherapy were performed. RESULTS: Three-year survival in the VA group was 80.1±6%, while in the BB group it was 56.6±7% (p0.05). Five-year survival among patients in the VA group was 39.4±7%, while in the BB group it was 2 times lower – 18.9±5% (p0.05). About 7% of patients in the study group survived for more than 8 years. CONCLUSIONS: The treatment regimen we developed for patients with locally advanced tongue cancer, which includes selective intra-arterial polychemotherapy followed by radiation therapy to the primary tumor and areas of regional metastasis, increased the median survival, three- and five-year survival.
Published Version
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