LONG-TERM OUTCOMES OF YOUNG PATIENTS AFTER SURGICAL CLOSURE OF VENTRICULAR SEPTAL DEFECT WITH EPOXY-TREATED XENO-PERICARDIAL “KEMPERIPLAS-NEO” PATCH

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HighlightsVentricular septal defect is the most common congenital heart defect requiring open-heart surgery. The epoxy-treated patch made from xeno-pericardium used to correct this defect was assessed from the standpoint of efficacy, safety, thrombogenicity and degree of calcification AnnotationAim. To assess long-term outcomes of ventricular septal defect closure using epoxy-treated xeno-pericardial “KemPeriplas-Neo” patch in children.Methods. This retrospective study included 42 patients aged 16 months to 18 years, diagnosed with ventricular septal defect (VSD, membranous and muscular) and undergoing VSD closure. The study did not include patients with congenital heart defects (CHD) and congenital and acquired valvular heart diseases. In the long-term follow-up, VSD patch closure (including pseudoaneurysms, fibrosis, recanalization of VSD and recurrence, macrocalcification) was assessed using postoperative transthoracic echocardiography (TTE).Results. Mean age of patients at the time of surgery was 67.4 ± 53.4 months (range 16–216 months), and at the time of the study 178.2 ± 35.9 months (range 101–243 months). The mean follow-up period was 111.5 ± 18.5 months (range 70.0–147 months). According to TTE results, there were no complications after procedure. Valve function after surgical closure of VSD was satisfactory. Reoperations were not required, and there were no cases of acute stoke and myocardial infarction in the follow-up period. Moreover, there were no in-hospital deaths and no long-term fatal outcomes.Conclusion. The data obtained indicate the safety and effectiveness of conducting ventricular septal defect closure using epoxy-treated xeno-pericardial “KemPeriplas-Neo” patch. The VSD patch did not disturb the movement of the interventricular septum, and it did not negatively affect the adjacent areas, including the aorta. However, it is necessary to increase the number of patients and conduct a comparative analysis with other types of patches (synthetic, glutaraldehyde–treated) for a more detailed study of the VSD patch efficacy.