Abstract
Introduction: Pancreatic neuroendocrine tumors (PNET) are a rare subgroup of tumors. For PNETs, the predictive factors for survival and prognosis are not well known. The aim of the present study was to investigated the clinicopathological and prognosis of the patients with resected pancreatic neuroendocrine tumors (PNET). Method: 42 patients with PNET underwent surgical treatment from April 1992 to June 2017. Data regarding the clinicopathologic factors of these patients were collected retrospectively. Factors influencing the prognosis of advanced gallbladder cancer after resection were analyzed by univariate and multivariate analysis. Result: The patients comprised of 18 men and 24 women. The mean age of the patients was 53.98±12.75 years. Nine cases (21.4%) were functional tumors and 33 cases (78.6%) were non-functional tumors. The mean tumor size was 2.99±2.08 cm. The most common location was tail (38.1%) and head (35.7%), followed body (21.4%), and body & tail(4.8%) in pancreas. The differences in the disease specific survival time as grading system based on Ki-67 and mitotic count were only statistically significant (P=0.015). The 5-year disease specific survival rates of patients with Grade 3 tumor was 0%. The T category (P=0.115), N category (P=0.299), TNM staging system (P=0.458), lymphovascular invasion (P=0.479), and perineural invasion (0.527) were not statistically significant factors. Conclusion: Patient with grade 3 PNET have worse postoperative prognosis. Therefore, we need careful monitoring after surgery.
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