Long-term Functional Connectivity Alterations in the Mismatch Negativity, P300 and N400 Language Potentials in Adults with a Childhood Acquired Brain Injury

Abstract

ABSTRACT Objective To investigate whether alterations in the functional connectivity of networks underlying phoneme perception and semantic-categorical processing persist in adulthood following childhood acquired brain injury (cABI). Methods EEG was recorded in seven adults with a cABI and seven matched controls during the administration of an inattentive and attentive phoneme-level oddball task and a categorical priming task. Functional connections underlying the mismatch negativity (MMN), P300 and N400 were compared between participant groups in five frequency bands by calculating the weighted phase lag index between 32 × 32 electrode pairs. Network modularity and path length were compared between the cABI and control group. Results We observed a positive network for MMN deviant processing in the low gamma band and N400 related processing in the alpha band, but a negative network for P300 standard processing in the theta band in cABI compared to control adults. No differences in graph measures of functional networks were observed between participant groups. Conclusions Alterations in the functional connectivity of speech perception and semantic-categorical processing networks persist in adulthood following cABI. Nevertheless, normal-like network properties in terms of local segregation and global integration are observed.