Abstract
Objective: The comparative effects of food restriction (FR), Diabecon treatment (DT) and their combined therapy (FR+DT) were studied in the regulation of alloxan-induced diabetes mellitus, alterations in thyroid hormones (TH) and oxidative stress.
 Methods: Young diabetic rats were either kept on 50% FR and/or DT (2 gm/Kg body weight) for two months and then alterations in serum glucose, insulin, TH concentrations, hepatic glycogen and pancreatic antioxidants along with oxidative stress markers were evaluated.
 Results: Significantly increased serum glucose, tissue stress markers with decreased TH, hepatic glycogen (P<0.0001 for all) and pancreatic antioxidants (P<0.05-0.001) were observed in diabetic rats. Rats kept on different therapies exhibited significant (P<0.05) improvements than diabetic rats in all studied parameters. FR+DT group showed a significantly more decrease in serum glucose (P<0.05) that FR or DT group, while in other parameters improvement was found to be more or less equally improved in all treated groups.
 Conclusion: FR appeared to mimic the effects of Diabecon in most of the indices. However, FR+DT appears to be more effective. Possibly both therapies ameliorate diabetes and oxidative stress following some common metabolic pathways.
Highlights
Diabetes mellitus (DM) and thyroid disease have become the most common endocrine abnormalities in recent years [1, 2]
We evaluated the alterations in serum glucose, insulin, hepatic glycogen and thyroid hormones (TH) concentrations
Rats kept on Diabecon treatment (DT), food restriction (FR) and DT+FR showed significant improvement in serum glucose (P
Summary
Diabetes mellitus (DM) and thyroid disease have become the most common endocrine abnormalities in recent years [1, 2]. Excessively generated free radicals were observed as an essential factor, which is believed to impair endocrine control and worsen metabolism [7]. Food restriction (FR) can improve these alterations by diminishing free radical generation and enhancing the expression of genes involved in antioxidant defense, insulin sensitivity, β-cell functions, nutrient metabolism; many times patients are unable to comply with this for a long time [6, 7]. Diabecon (a poly-herbal formulation) was taken as test drug. It is a mixture of forty-two medicinal herbs, having protective activities [10, 11], but its effect on diabetic complications including TH concentration was not studied, till date. Hyperglycemia deteriorates the pancreatic antioxidant system [4, 7, 8], the possible free radical protective activities were measured in the pancreas
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