Long noncoding RNA expression in peripheral blood mononuclear cells and suicide risk in Chinese patients with major depressive disorder.

Xuelian Cui,Jim Lu,Kunhong Jiang,Aifang Zhong,Shengdong Chen,Liyi Zhang,Mingjun He,Wanshuai Li,Wei Niu,Lingming Kong

doi:10.1002/brb3.711

Xuelian Cui, Jim Lu + Show 8 more

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https://doi.org/10.1002/brb3.711

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Background WHO stated that nearly one million people commit suicide every year worldly, and 40% of the suicide completer suffered from depression. The primary aim of this study was to explore the association between long noncoding RNAs (lncRNAs) expression in peripheral blood mononuclear cells (PBMCs) and suicide risk of patients with major depressive disorder (MDD).MethodsUsing Human LncRNA 3.0 microarray profiling which includes 30,586 human lncRNAs and RT‐PCR, six down‐regulated lncRNAs were identified differentially expressed in MDD patients. According to suicidal ideation and suicidal attempt, the suicide risk of MDD patients was classified into suicidal ideation versus no suicidal ideation groups, and past attempt versus no past attempt groups, respectively. The expression of six lncRNAs in MDD patients and controls were examined by RT‐PCR.ResultsThe expression of six lncRNAs had significant differences between no suicidal ideation, suicidal ideation, and controls; corresponding lncRNAs associated with suicidal attempt had remarkable differences between no past attempt, past attempt, and controls. Additionally, only the expression of lncRNAs in suicidal ideation group and past attempt group markedly declined compared with controls.ConclusionsThis study indicated that the expression of six down‐regulated lncRNAs had a negative association with suicide risk in MDD patients, and the expression of lncRNAs in PBMCs could have the potential to help clinician judge the suicide risk of MDD patients to provide timely treatment and prevent suicide.

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WHO stated that nearly one million people commit suicide every year worldly, and 40% of the suicide completer suffered from depression
Using chi-square and t-test, there were no significant differences between the suicide risk groups and controls with regard to age, gender, ethnicity, and marital status, but the HAMD scores were significantly different (Table 1)
Candidate genes have been investigated in the postmortem brains of suicide victims, such as Gamma-amino butyric acid type A (GABAA) receptor (Poulter et al, 2008), Glucocorticoid receptor (Labonte et al, 2012), and brain-derived neurotrophic factor (BDNF) promoter (Keller et al, 2010), but there is common genetic predisposition between SZ and major depressive disorder (MDD)

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Introduction

WHO stated that nearly one million people commit suicide every year worldly, and 40% of the suicide completer suffered from depression. The primary aim of this study was to explore the association between long noncoding RNAs (lncRNAs) expression in peripheral blood mononuclear cells (PBMCs) and suicide risk of patients with major depressive disorder (MDD). Results: The expression of six lncRNAs had significant differences between no suicidal ideation, suicidal ideation, and controls; corresponding lncRNAs associated with suicidal attempt had remarkable differences between no past attempt, past attempt, and controls. Only the expression of lncRNAs in suicidal ideation group and past attempt group markedly declined compared with controls. Conclusions: This study indicated that the expression of six down-regulated lncRNAs had a negative association with suicide risk in MDD patients, and the expression of lncRNAs in PBMCs could have the potential to help clinician judge the suicide risk of MDD patients to provide timely treatment and prevent suicide

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