Abstract
Long non-coding RNAs learn the importance of being in vivo
Highlights
In the past few years, the long non-coding RNA field has been dealt some major surprises
In 2004, the Nature editor refused to send our paper on Evf2 long non-coding RNA (lncRNA) transacting transcriptional activity out for peer review, stating that a knockout mouse model was necessary
Mice lacking the well-characterized lncRNAs, NEAT1, required for paraspeckles (Nakagawa et al, 2011), MALAT1, localized in nuclear speckles, (Nakagawa et al, 2012), or HOTAIR, recruitment of histone modification complexes that regulate Hox genes (Schorderet and Duboule, 2011; Li et al, 2013), challenge previous data obtained in cell lines
Summary
In the past few years, the long non-coding RNA (lncRNA) field has been dealt some major surprises. These lncRNAs regulate imprinting and/or dosage compensation, and were studied almost exclusively in animal models (mice or Drosophila). Unlike the majority of previous lncRNA experiments, initial SRA, Evf2 and HOTAIR studies relied on cell lines to assay for lncRNA activity.
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