Abstract
To identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients. We conducted an epigenome-wide association study (EWAS): the most promising markers were identified in 233 TNBC case-control pairs (discovery set) and subsequently validated in an independent validation set (57 TNBC patients and 124 controls). cg06588802 (LINC00299/ID2) showed a higher methylation in TNBC patients compared with controls (discovery set: 3% increase, p-value=0.0009; validation set: 2% increase, p-value=0.01). Consistent results at four neighboring methylation probes and the strong negative correlation (rho=-0.93) with LINC00299 expression add plausibility to this result. Hypermethylation of LINC00299 in peripheral blood may constitute a useful circulating biomarker for TNBC.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
