Abstract
BackgroundHereditary triple-negative breast cancer patients have better recurrence-free survival than triple-negative sporadic ones. High expression of some of the miRNAs is related to worse overall and disease-free survival of triple-negative breast cancer patients. The attempt to associate expression level of some miRNA in triple-negative hereditary and sporadic breast cancers to disease specific survival was performed in this study.Material and methodsStudy group was made of 18 triple-negative breast cancer patients harboring the BRCA1 gene mutations and 32 triple-negative sporadic breast cancer patients. Quantitative amount of mir-10b, mir-21, mir-29a, mir-31, and mir-214 by real-time PCR was assessed. The disease-specific survival in relation of high and low levels of some of the miRNAs was analyzed using Log-rank (Mantel-Cox) test.ResultsMiR-214 showed significantly higher expression level in sporadic tissues than in hereditary ones (p = 0.0005). Triple-negative breast cancer patients with high level of miR-214 showed significantly worse disease-specific survival than patients with low level (p = 0.0314).ConclusionsOur finding suggests that miR-214 possibly could be used as a potential prognostic biomarker for triple-negative breast cancer patients.Electronic supplementary materialThe online version of this article (doi:10.1186/s13053-015-0028-z) contains supplementary material, which is available to authorized users.
Highlights
Hereditary triple-negative breast cancer patients have better recurrence-free survival than triplenegative sporadic ones
The majority of these tumors are sporadic while five to 10% are hereditary, and significant proportion of them is due to the inherited mutations either in the BRCA1 or BRCA2 gene [2,3]
Material and methods Eighteen TN breast cancer patients harboring the BRCA1 gene mutations and 32 triple-negative sporadic breast cancer patients hospitalized at Pauls Stradins Clinical University Hospital and/or Latvian Oncology Center from 2004 to 2011 were involved in this study
Summary
Hereditary triple-negative breast cancer patients have better recurrence-free survival than triplenegative sporadic ones. High expression of some of the miRNAs is related to worse overall and disease-free survival of triple-negative breast cancer patients. The attempt to associate expression level of some miRNA in triple-negative hereditary and sporadic breast cancers to disease specific survival was performed in this study. In the year 2008 approximately 1.38 million new cases were diagnosed, and 458,400 females died from this malignancy [1]. The majority of these tumors are sporadic while five to 10% are hereditary, and significant proportion of them is due to the inherited mutations either in the BRCA1 or BRCA2 gene [2,3].
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