Abstract
The use of nanomedicine has increased enormously, especially in the field of gene delivery and targeted drug delivery. The objective of current review to identify long-chain polymeric carbohydrate dependent nano-composites in tissue engineering such Gellan gum incorporated TiO2 nanotubes, Poly(vinyl) alcohol-gellan gum-based nanofiber, Cross-linked gellan/PVA nanofibers, Nanocellulose reinforced gellan-gum hydrogels, Dextran and sol-gel derived bioactive glass-ceramic nanoparticles, Aminated β-Cyclodextrin-Modified-Carboxylated Magnetic Cobalt/ Nanocellulose Composite, Chitosan-chitin nanocrystal composite scaffolds, Sodium alginate-xanthan gum-based nano-composite scaffolds, Nano-hydroxyapatite Pullulan/dextran polysaccharide composite, Chitosan/Carbon nanofibers Scaffolds, Nano-bio composite scaffold of chitosan–gelatin–alginate–hydroxyapatite, Alginate/gelatin scaffolds with homogeneous nano apatite coating,Nano-hydroxyapatite-alginate-gelatinmicrocapsule,Poly(ε-caprolactone)/keratin nano fibrousmats, Keratin nanoparticles-coating electrospun PVA nanofiber, Nano-hydroxyapatite/chitosan/chondroitin sulfate/hyaluronic acid and Chitosan/chondroitin sulfate/nano-bioglass. The current review has identified a list of medicinal herbs that have been incorporated into long chain polymeric carbohydrate-based nano-composites
 Peer Review History: 
 Received 15 July 2020; Revised 13 August; Accepted 28 August, Available online 15 September 2020
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 Received file 
 
 Average Peer review marks at initial stage: 6.5/10
 Average Peer review marks at publication stage: 8.0/10
 Reviewer(s) detail:
 Name: Shahinga Vanji
 Affiliation:
 E-mail: shahin.gavanji@khuisf.ac.ir
 
 Name: Dr. Asia Selman Abdullah
 Affiliation: University of Basrah, Iraq
 E-mail: asiaselman2016@gmail.com
 
 Comments of reviewer(s): 
 
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Highlights
The current review has identified a list of medicinal herbs that have been incorporated into long chain polymeric carbohydrate-based nano-composites
Nanomedicine has gained a lot of interest due to its vast application
The materials provide an analogous environment to the extracellular matrix (ECM) and provide an induced rate of synthesis or growth of new tissues
Summary
Nanomedicine has gained a lot of interest due to its vast application. Physical and chemical attributes of nanomaterials have lengthened its application in the field of biological science and biomedical engineering such as biological imaging, drug delivery, biomolecular sensing, and Infectious Diseases[1]. Inorganic nano materials possess intrinsically physicochemical properties and good biocompatibility, as a result, they are used in different applications such as bio imaging, targeted drug delivery, and cancer therapies, whereas the Metal-organic framework is porous hybrid polymer-metal composites[4,5]. They possess many biomedical applications due to their excellent porosity, high loading capacity, biodegradebility, and ease of surface modification when compared to others[6,7]. Monosaccharides and disaccharides are bonded through covalent linkage to develop a long chain of polymer-based carbohydrates They consist of other functional groups such as pyruvate, sulfate, and methyl. Human dermal fibroblast Cell proliferation behaviour of (3T3L1) cells in tissue human dermal fibroblast cells engineering application (3T3L1)
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