Abstract
Dendrimers are hyper-branched macromolecules having tree like structure, consisting of a core molecule and alternating layers of monomers. Due to their unique architecture these have improved physical and chemical properties like high solubility, miscibility and reactivity. Dendrimers consist of well defined size, shape, molecular weight and monodispersity. These properties formulate the dendrimers a suitable carrier in drug delivery application. These are built from number of molecular entities of colloidal particles that exists in equilibrium with the molecules or ions in nature and due to these increases the solubility of poorly soluble drugs. Dendrimers have the ability to encapsulate and bind the guest molecule can be used for solubility enhancement, sustained release and various drug delivery applications. The terminal groups are modified to attach biologically active substances for targeting purpose. Dendrimers are suitable for a wide range of targeted drug delivery, controlled drug delivery, gene delivery and industrial applications. This review gives concise information about the dendrimers, its synthesis, characterization and application in drug delivery. Peer Review History: Received 9 June 2017; Revised 4 July; Accepted 9 July, Available online 15 July 2017 Academic Editor: Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, olorunsolaeo@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 4.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Dr. Areen Alshweiat, University of Szeged, Hungary, areen.alshweiat@hu.edu.jo Dr. Liliya Logoyda, Horbachevsky Ternopil State Medical University, Ukraine, logojda@tdmu.edu.ua This article has been cited by: Awad, Linh I and N. Jber. “Synthesis of Dendrimers Liquid Crystalline Materials based on 1,3,5-triphenylbenzene.” Journal of drug delivery 9 (2019): n. pag. Pubmed
Highlights
INTRODUCTIONAt present scenario many researchers are working to deliver the drug with improved bioavailability, enhancement in solubility, to hit the target site to produce therapeutic effects, and to avoid the toxic effects[1]
Dendrimers are hyper-branched macromolecules having tree like structure, consisting of a core molecule and alternating layers of monomers
Each step of the reaction must be determined to full completion to prevent mistakes in the dendrimer, which can grounds trailing generations
Summary
At present scenario many researchers are working to deliver the drug with improved bioavailability, enhancement in solubility, to hit the target site to produce therapeutic effects, and to avoid the toxic effects[1]. In dendritic structures number of terminal group increases exponentially with a linear increase in the generation of dendrimer. Dendrimers structures can be used to load and store a wide range of organic or inorganic molecules by encapsulation and absorption on surface. Lysine with its alkyl amino sidechain serves as a good monomer for the introduction of numerous of branching points This type of dendrimer used in biological applications, e.g. vaccine and diagnostic research. Size and shape Dendrimers shows improved physical and chemical properties due to their molecular architecture. Polyvalency It shows the outer arrangement of reactive groups on the exterior of dendrimer nanostructure Polyvalency it provides for versatile functionalization; it produce multiple interactions with biological receptor sites, for example, in the design of antiviral therapeutic agents. The appropriate type (and degree) of functionalisation will results in the desired loading capacity[27]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
