Abstract
Single-voxel proton magnetic resonance spectroscopy has been shown to be a promising tool for assessing creatine [1] and myocardial triglycerides in humans [2, 3, 4]. A focus of interest is the correlation between triglyceride content in the myocardium and cardiac dysfunction [5]. While spectral information from a single volume is sufficient when alterations with global effects on the heart are studied, a demand for higher and flexible spatial resolution exists when probing local changes. The objective of the current work was to implement a navigated local-look Echo-Planar Spectroscopic Imaging (EPSI) sequence for assessment of triglyceride and creatine content in the myocardium in vivo.
Highlights
Single-voxel proton magnetic resonance spectroscopy has been shown to be a promising tool for assessing creatine [1] and myocardial triglycerides in humans [2, 3, 4]
Watersuppressed and unsuppressed Echo-Planar Spectroscopic Imaging (EPSI) data were acquired in healthy volunteers during free breathing in an average scan time of 2:30 min per average depending on heart rate and respiratory navigator efficiency
Beside spectra from a region of interest located in the septal wall, spectra from six regions of interest from the mid-cavity are shown for the EPSI scans
Summary
Single-voxel proton magnetic resonance spectroscopy has been shown to be a promising tool for assessing creatine [1] and myocardial triglycerides in humans [2, 3, 4]. A focus of interest is the correlation between triglyceride content in the myocardium and cardiac dysfunction [5]. While spectral information from a single volume is sufficient when alterations with global effects on the heart are studied, a demand for higher and flexible spatial resolution exists when probing local changes. The objective of the current work was to implement a navigated local-look Echo-Planar Spectroscopic Imaging (EPSI) sequence for assessment of triglyceride and creatine content in the myocardium in vivo
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