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Abstract
FOLLOWING the adventitious finding that lymphocytes from patients with malignant (but not benign) neoplasia are sensitized to encephalitogenic basic protein of myelin (EF)1 and to a protein similarly extracted from a variety of tumours2, a logical step would be to determine the subcellular localization of the specific antigen(s) on or within the cancer cell and whether or not the antigen continues to be associated with human malignant (or transformed) cells long maintained in culture. If this were so, then such cultures might serve as a convenient and standard source for an antigen of considerable potential in the diagnosis—and perhaps also the treatment—of malignant disease. The allied question of the identity and uniqueness of the antigens extractable from different cell lines or tumours will be the subject of a separate communication.
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