Abstract
The human prealbumin gene was tried to map by the analysis of gene dose effects on Southern hybridization bands of various chromosome 18 abnormalities. The32P-labeled probe “pPA1” which contains the prealbumin cDNA hybridized to an 11 kb and a 4.6 kbHind III-fragments from cells each of which has a different chromosome 18 constitution. Autoradiograms (hybridization bands) for pseudodicentric 18 (trisomy of almost whole of a chromosome 18) showed 1.5-fold density compared with those of the normal diploid. Autoradiograms for trisomy for 18q21.3-qter and monosomies for 18p11.2-pter and for 18q21.1-q21.3 were all not different in density from those of the diploid control. Our results provide evidence for regional assignment of this gene to 18p11.1-q12.3, most likely to cen-q12.3.
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Schedule a callMore From: Jinrui idengaku zasshi. The Japanese journal of human genetics
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