Localization of accessory pathways in Wolff-Parkinson-White syndrome by high-resolution magnetocardiographic mapping

Abstract

Fifteen patients with Wolff-Parkinson-White syndrome were studied with standard 12-lead electrocardiogram, invasive electrophysiologic study, and high-resolution magnetocardiographic (MCG) mapping. In addition, intraoperative epicardial mapping was performed in seven surgically treated patients. The MCG characteristics of ventricular preexcitation for different locations of the atrioventricular accessory pathways were described in terms of morphology and field patterns. Three mathematical source models in semi-infinite conducting space were used for localization computations: the current dipole model, the truncated current multipole model and the magnetic dipole model. Finally, the localization results of MCG and invasive mappings and electrocardiograms were compared. The mean three-dimensional distance between the localization results obtained from MCG maps and electrophysiologic study was 3.9 cm for the magnetic dipole model, 4.8 cm for the truncated current multipole model, and 7.3 cm for the current dipole model. The corresponding distances in the seven intraoperatively mapped cases were 2.3 cm for the magnetic dipole model, 5.2 cm for the truncated current multipole model, and 6.3 cm for the current dipole model. In conclusion, noninvasive MCG mapping may significantly contribute to the invasive catheter mapping for optimal preoperative localization of preexcitation site and atrioventricular accessory pathways in Wolff-Parkinson-White syndrome.