Abstract
Significant strides will be made in the field of computerized electrocardiology through the development of artificial intelligence (AI)-enhanced ECG (AI-ECG) algorithms. Yet, the scientific discourse has primarily relied upon on retrospective analyses for deriving and externally validating AI-ECG classification algorithms, an approach that fails to fully judge their real-world effectiveness or reveal potential unintended consequences. Prospective trials and analyses of AI-ECG algorithms will be crucial for assessing real-world diagnostic scenarios and understanding their practical utility and degree influence they confer onto clinicians. However, conducting such studies is challenging due to their resource-intensive nature and associated technical and logistical hurdles. To overcome these challenges, we propose an innovative approach to assess AI-ECG algorithms using a virtual testing environment. This strategy can yield critical insights into the practical utility and clinical implications of novel AI-ECG algorithms. Moreover, such an approach can enable an assessment of the influence of AI-ECG algorithms have their users. Herein, we outline a proposed randomized control trial for evaluating the diagnostic efficacy of new AI-ECG algorithm(s) specifically designed to differentiate between wide complex tachycardias into ventricular tachycardia and supraventricular wide complex tachycardia.
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