Abstract
Objective: To determine the effect of Vitamin D3 on the rate and amount of orthodontic tooth movement in humans when injected locally at the site. Materials and Methods: A prospective, split-mouth clinical trial was carried out on 15 subjects who were referred for bilateral therapeutic extraction of the first premolars followed by canine retraction in the maxillary arch. Vitamin D3 in a vehicle of local anesthetic solution was injected into the buccal vestibule immediately distal to the canine to be retracted on the experimental side; on the contralateral side, only local anesthetic solution as control was injected into the correspnding site on the 7th, 21st, and 47th days of canine retraction. The amount of canine retraction was assessed using the palatal rugae as stable landmarks, and the values obtained were compared using preand postcanine retraction occlusograms. Results: The experimental teeth whose gingivae had received injections containing Vitamin D3 had moved considerably less than had the matched control teeth (P , .001). Conclusions: Localized injection of vitamin D3 produces a significantly decreased rate and amount of tooth movement in humans. (Angle Orthod. 0000;00:000–000.)
Published Version
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