Local Atomic and Electronic Structures of Superparamagnetic Nanoparticles Based on Iron Oxides for Local Hyperthermia in Oncology

Abstract

Iron oxide-based superparamagnetic nanoparticles (Fe3O4) are obtained using the solvothermal synthesis. Both the pure nanoparticles of Fe3O4 and nanoparticles doped by samarium and gadolinium are obtained to manipulate their characteristics. The materials were investigated using X-ray diffraction, X-ray fluorescence, vibrating-sample magnetometry, electron microscopy, electron diffraction, and FT-IR spectroscopy. The nanoparticles have the average size of about 22.3 nm, a crystal lattice of magnetite, and superparamagnetic characteristics at room temperature. Based on the FT-IR spectroscopy, all the synthesized nanoparticles included in their composition a polyethylene glycol coating. The hyperthermic characteristics (SAR and ILP) are determined for the obtained nanoparticles in an alternating magnetic field (AMF). The promising prospects of using the discussed superparamagnetic nanoparticles based on iron oxide particles doped by the atoms of the rare-earth elements for the local magnetic hyperthermia are shown.