Local Application of Propranolol and Treatment of Diabetic Vulovagnitis

Salwa Samir Anter

doi:10.19080/jgwh.2018.11.555801

Abstract

Background: Propranolol (PRO) is a commonly used non-selective beta-adrenergic receptor antagonist used in the treatment of hypertension, angina, anxiety, cardiac arrhythmia, hyperthyroidism, essential tremor and as a prophylaxis against migraine, variceal bleeding and myocardial infarction diabetes mellitus (T2DM) is a debilitating disease with multiple complications resulting from hyperglycemia, inflammation, and possibly immune dysfunction. It is well established that yeasts thrive in a sugar-rich environment, and therefore, it is logical to hypothesize that high glucose concentrations in patients with diabetes may be responsible for promoting the occurrence and recurrence of candidiasis. There are several potential mechanisms by which hyperglycemia may facilitate vaginal candida colonization. Hyperglycemia impairs various aspects of host defense, including neutrophils and complement proteins, and also promotes the virulence of infecting organisms in patients with diabetes. To evaluate the effective of propranolol solution application in treatment of diabetic vulvovaginitis.Method: Diabetic patients were diagnosed diabetic vulvovaginitis were divided into test group and control group with the method of randomized controlled trial. The patients of test group were treated with local application of propranolol solution once a day. The patients of control group were treated vaginal douch applied locally on vaginal and local on vulva once a day. The course of treatment was 10-d.Result: The curative indexes included the improvement of symptoms and signs of Vulvovaginitis first pain relief, burning sensation, hotness, swelling and vaginal discharge, in group. A symptoms cures in 80%,in group B symptoms cure in 12% side effect of treatment in group A no side effect in group A nor in group B vaginal.Conclusion: Propranolol application promising for the treatment of diabetic Vulvovaginitis in symptomatic women it combat symptoms.

Highlights

Vulvovaginitis (VV) is a commonly encountered symptom in the diabetes clinic [1]
Panel Yu-et al 2012 in his study propranolol as a local anesthetic is more potent than lidocaine, and the sensory/ nociceptive blockade caused by propranolol was longer than that caused by lidocaine
Group A Included 30 patients were treated locally with local applications propranolol Group B Included 30 patients were treated locally vaginal douch. women found to have diabetic vulovagnitis were provided a course of oral and/or vaginal treatment and those who were not responsive to treatment were enrolled in study The Inclusion criteria were symptoms vaginal discharge, and vulvitis redness hotness, painfual/or other signs that, if combined, were diagnosed as diabetic Vulovagnitis

Summary

Introduction

Many patients are diagnosed to have diabetes when they present with symptoms suggestive of VV. Propranolol (PRO) is a commonly used non-selective beta-adrenergic receptor antagonist used in the treatment of hypertension, angina, anxiety, cardiac arrhythmia, hyperthyroidism, essential tremor and as a prophylaxis against migraine, variceal bleeding and myocardial infarction diabetes mellitus (T2DM) is a debilitating disease with multiple complications resulting from hyperglycaemia, inflammation, and possibly immune dysfunction. It is well established that yeasts thrive in a sugar-rich environment, and it is logical to hypothesize that high glucose concentrations in patients with diabetes may be responsible for promoting the occurrence and recurrence of candidiasis. Hyperglycaemia impairs various aspects of host defense, including neutrophils and complement proteins, and promotes the virulence of infecting organisms in patients with diabetes. The patients of test group were treated with local application of propranolo solution once a day.

Objectives

Methods

Conclusion