Local Application of Propranolol and Treatment of Diabetic Vulovagnitis

Abstract

Background: Propranolol (PRO) is a commonly used non-selective beta-adrenergic receptor antagonist used in the treatment of hypertension, angina, anxiety, cardiac arrhythmia, hyperthyroidism, essential tremor and as a prophylaxis against migraine, variceal bleeding and myocardial infarction diabetes mellitus (T2DM) is a debilitating disease with multiple complications resulting from hyperglycemia, inflammation, and possibly immune dysfunction. It is well established that yeasts thrive in a sugar-rich environment, and therefore, it is logical to hypothesize that high glucose concentrations in patients with diabetes may be responsible for promoting the occurrence and recurrence of candidiasis. There are several potential mechanisms by which hyperglycemia may facilitate vaginal candida colonization. Hyperglycemia impairs various aspects of host defense, including neutrophils and complement proteins, and also promotes the virulence of infecting organisms in patients with diabetes. To evaluate the effective of propranolol solution application in treatment of diabetic vulvovaginitis.Method: Diabetic patients were diagnosed diabetic vulvovaginitis were divided into test group and control group with the method of randomized controlled trial. The patients of test group were treated with local application of propranolol solution once a day. The patients of control group were treated vaginal douch applied locally on vaginal and local on vulva once a day. The course of treatment was 10-d.Result: The curative indexes included the improvement of symptoms and signs of Vulvovaginitis first pain relief, burning sensation, hotness, swelling and vaginal discharge, in group. A symptoms cures in 80%,in group B symptoms cure in 12% side effect of treatment in group A no side effect in group A nor in group B vaginal.Conclusion: Propranolol application promising for the treatment of diabetic Vulvovaginitis in symptomatic women it combat symptoms.