Abstract
Increased intrauterine pressure due to exaggerated myometrial contractions is an important factor in the pathogenesis of dysmenorrhea. In a recent study it was found that glyceril trinitrate (GTN) caused a significant reduction in the contraction frequency of human myomertrial strips w1x. In order to evaluate the efficacy of GTN ointment (Nitrobid 2%, Marion Laboratories Pharmaceuticals, USA) in treating primary dysmenorrhea, we performed a double-blind randomized placebocontrolled study on 112 unmarried students, with the complaint of moderate to severe primary dysmenorrhea. They were between 18–30 years of age with normal BMI (19–27) and all had normal pelvic ultrasound. None of them had a history of diseases such as anemia, previous pelvic surgery or cardiovascular diseases. They were randomly divided in two groups using odd and even numbers, 56 of the students received 5 mg GTN 1% ointment and another 56 received placebo. Before starting treatment, severity of pain was recorded using a visual scale method, then 3 cm of ointment A (GTN 1%) or ointment B (placebo) was applied on the skin of the abdomen below the umbilicus using special paper. The severity of pain *Corresponding author.
Published Version
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