Abstract
Non-union is a major clinical problem in the healing of fractures, especially in patients with osteoporosis. The systemic administration of drugs is time consuming and large doses are demanding and act slowly, whereas local release acts rapidly, increases the quality and quantity of the bone tissue. We hypothesize that local delivery demonstrates better therapeutic effects on an osteoporotic fracture. The aim of this paper is to investigate the effect of the local application of ibandronate loaded with a collagen sponge on regulating bone formation and remodeling in an osteoporotic rat model of fracture healing. We found that the local delivery of ibandronate exhibited excellent effects on improving the bone microarchitecture and suppressed effects on bone remodeling. At 4 weeks, more callus formation and improvement of mechanical character and microstructure were observed in a local delivery via μCT, mechanical test, histological research and serum analysis. The suppression of bone remodeling was compared with a systemic treatment at 12 weeks, and the structural mechanical properties and microarchitecture were also improved with local delivery. This research identifies an earlier, safer and integrated approach for local delivery of ibandronate with collagen and provides a better strategy for the treatment of osteoporotic fracture in rats.
Highlights
Osteoporosis (OP) is a common disease that is characterized by the loss of bone mass, the deterioration of bone microstructure and increased fragility in elderly people, and it is classified as primary and secondary osteoporosis
Radiographs showed that the callus formed in the Sham group was high in density, partly union and similar to cortical bone at 4 weeks
The experiment duration last for 12 weeks, and an experiment lasting for more than 12 weeks until the remodel phase completed will be conducted to test the biomechanical properties in IB treatment groups in future. This is the first report demonstrating the short- and long-term effects of local IB combined with collagen on bone microarchitecture, mechanical properties and histology in osteoporotic fractures
Summary
Osteoporosis (OP) is a common disease that is characterized by the loss of bone mass, the deterioration of bone microstructure and increased fragility in elderly people, and it is classified as primary and secondary osteoporosis. Primary OP containing idiopathic osteoporosis is a common clinical disease, especially in postmenopausal women and elderly people, and the rate is higher as the life span of people is prolonged. The author from VSD is a senior fellow apprentice of the first author who focused on basal experiment in his doctor research, and he guided the procedure of ovariectomy before conducting this experiment. He has left the company and has a job in another company. The specific role of this author is articulated in the ‘author contributions’ section
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