Abstract
Pantocaine, procaine, xylocaine and cocaine were found to interact with the polyanionic matrix surrounding the nodal axon membrane of peripheral myelinated nerve. Their affinity for nodal anionic sites was found to lie between that of mono- and divalent inorganic cations. The affinity was related to the polar character of local anaesthetic molecules. The possible significance of these interactions is discussed in terms of current theories regarding the action of local anaesthetics on nerve impulse conduction.
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