Abstract
Abstract Six diethylaminoacetyl derivatives of general formula (III) are more potent than lignocaine as local anaesthetics. All cause erythema or necrosis of guinea-pig skin on intradermal injection except III, R = NH2, R' = H, and R = O(CH2)2Ph. This compound is several times more potent than lignocaine and in equipotent concentrations did not cause any tissue damage to skin on intradermal injection.
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