Abstract
Lobular neoplasia of the breast refers to lesions characterized by atypical lobular hyperplasia and by lobular carcinoma in situ. Lobular neoplasia is not only a risk factor but a non-mandatory precursor for the development of invasive carcinoma. Pleomorphic lobular carcinoma in situ is a subtype of lobular neoplasm with an aggressive behavior and high nuclear grade that can mimic high-grade ductal carcinoma in situ. Management and monitoring the patients with lobular neoplasm is controversial, especially when diagnosis is made through core biopsy. Molecular and genomic studies have been able to identify genes that can dispel doubts as to its pathogenesis and allow an approach that may lead to safer and more appropriate therapeutic approaches. This review seeks to describe the most up-to-date approaches to lobular neoplasia of the breast.
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