Abstract
Abstract Epilepsy surgery is an established therapy for pharmacoresistant focal epilepsy. The contribution of MEG in presurgical evaluation compared to long-term video-EEG-monitoring is illustrated concerning at the resolution of anatomical lobes the additional benefit of MEG investigation in cases with ambiguous or without EEG findings. In total 84 subsequent patients with intractable focal epilepsy who underwent surgical treatment were included. Percentages of presurgical results located in one anatomical lobe of both diagnostic means were analyzed. In cases with a diagnostic finding, MEG localized in 84% within one anatomical lobe, ictal EEG in 70%, interictal EEG in 64%. In 20 of 84 patients no clear localization within one lobe was found either in interictal or in ictal EEG. In 10 of these cases MEG localized within one lobe matching the resected lobe. Five patients became seizure free and five had at least 50% reduction of seizure rate 1 year after resection. In summary MEG yields an important contribution to focus hypothesis in the workup for epilepsy surgery.
Published Version
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