Abstract
Our study aimed to investigate the role of long non-coding RNAs (lncRNA) TP73-AS1 in retinoblastoma (Rb). In the present study, we found that TP73-AS1 was up-regulated, while miR-139–3p was down-regulated in Rb. TP73-AS1 and miR-139-3p were inversely correlated in Rb tissues. In cells of Rb cell lines, overexpression of miR-139-3p failed to affect TP73-AS1, while TP73-AS1 overexpression caused the down-regulated miR-139-3p. TP73-AS1 overexpression caused promoted proliferation of Rb cells but showed no significant effects on cell migration and invasion. miR-139-3p overexpression played an opposite role and attenuated the effects of TP73-AS1 overexpression. Therefore, lncRNA TP73-AS1 may down-regulate miR-139-3p to promote Rb cell proliferation.
Highlights
Retinoblastoma (Rb) is a common and deadly intraocular tumor that mainly affects children [1]
The present study investigated the involvement of TP73-AS1 in Rb and explored its functions in this disease
We showed that TP73-AS1 was up-regulated in Rb and promoted Rb cell proliferation by down-regulating miR-139-3p, which has been characterized as a tumor suppressive miRNA in Rb [13]
Summary
Retinoblastoma (Rb) is a common and deadly intraocular tumor that mainly affects children [1]. One out of 18000 to 30000 live births will develop Rb worldwide [2]. Without proper treatment, development of Rb is rapid and brain metastasis is common, leading to high mortality rate [3]. Chemotherapy is usually successful in the treatment of group A–C patients, while ocular survival rate of group D after systemic chemotherapy is only 10–47% [4]. This rate in group E patients is close to 0 [5,6].
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